Novel Role of T Cells and IL-6 (Interleukin-6) in Angiotensin II–Induced Microvascular Dysfunction
نویسندگان
چکیده
منابع مشابه
Human marrow stromal cells: response to interleukin-6 (IL-6) and control of IL-6 expression.
Production of interleukin-6 (IL-6) by marrow stromal cells from human long-term marrow cultures and from stromal cells transformed with simian virus 40 was examined. As with other cultured mesenchymal cells, unstimulated stromal cells produced undetectable amounts of IL-6 mRNA when assayed by Northern blots. However, within 30 minutes after exposure of transformed marrow stromal cells to the in...
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The inductiott of innuute response requires the interadiort atnong ittttttutroco,ilpetent cells, accessory tnolecules and cytokines. Of these cytokines, IL-6, a 26 kD potypeptide, plays a najor role on the innune re.\ponse. The roles of this cytokine on the B and T cell developntent are reviewed brieJly. In the presence of other cytokines, IL-6 act.s on antige,t dependent-tertninal dffirentiati...
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Tumour invasion and trophoblastic invasion share the same biochemical mediators: the matrix metalloproteinases (MMP) and their inhibitors. In contrast to tumour invasion of a host tissue, trophoblastic invasion during implantation and placentation is stringently controlled both in tissue localization and developmental stage. The factors responsible for these important regulatory processes are u...
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Curcumin has been shown to have numerous cytotoxic effects on cancer stem cells (CSCs). This is due to its suppression of the release of cytokines, particularly interleukin (IL)-6, IL-8 and IL-1, which stimulate CSCs, and also to its effects at multiple sites along CSC pathways, such as Wnt, Notch, Hedgehog and FAK. In spite of its multiple actions targeting CSCs, curcumin has little toxicity a...
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Cytokines are essential modulators of the immune response. In the last decade there has been a number of cytokines considered targets for the development of biological therapies with the goal of blocking their activities and modulate the course of the immune response, primarily in the context of inflammatory diseases. IL-6 was first identified in the mid-1980s [1], but for almost two decades th...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2019
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.118.12286